Home | Aging-Related Terms Glossary | Neurofibrillary Tangle A B C D E F G H I J K L M N O P Q R S T U v W X Y Z Home | Aging-Related Terms Glossary | Neurofibrillary Tangle Neurofibrillary Tangle Abnormal accumulations of twisted protein fibers in the brain, commonly seen in Alzheimer’s disease.